Synaptic inhibition and gamma-aminobutyric acid in the mammalian central nervous system
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- OBATA Kunihiko
- National Institute for Physiological Sciences
書誌事項
- タイトル別名
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- Synaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system
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説明
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons. γ-Aminobutyric acid (GABA), non-protein amino acid formed by decarboxylation of glutamic acid, is a principal neurotransmitter at inhibitory synapses of vertebrate and invertebrate nervous system. On one hand glutamic acid serves as a principal excitatory neurotransmitter. This article reviews GABA researches on; (1) synaptic inhibition by membrane hyperpolarization, (2) exclusive localization in inhibitory neurons, (3) release from inhibitory neurons, (4) excitatory action at developmental stage, (5) phenotype of GABA-deficient mouse produced by gene-targeting, (6) developmental adjustment of neural network and (7) neurological/psychiatric disorder. In the end, GABA functions in simple nervous system and plants, and non-amino acid neurotransmitters were supplemented.<BR><BR>(Communicated by Masanori OTSUKA, M.J.A.)
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 89 (4), 139-156, 2013
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390282679122302208
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- NII論文ID
- 130003365113
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- NII書誌ID
- AA00785485
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- COI
- 1:STN:280:DC%2BC3srkt1ymsw%3D%3D
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 024465135
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- PubMed
- 23574805
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可