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New analogues of rosaramicin isolated from a Micromonospora strain. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
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- FUNAISHI KOHTAROU
- Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
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- KAWAMURA KENJI
- Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
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- SATOH FUMIO
- Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
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- HIRAMATSU MUNEYO
- Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
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- HAGIWARA MASAYUKI
- Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
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- OKANISH MASANORI
- Exploratory Research Laboratory, Banyu Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- New analogues of rosaramicin isolated from a Micromonospora strain
- I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
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Description
Antibiotics 6108 A1, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A4 and M-4365 A1 from the cultured broth of strain BA06108 which was assigned to be a new species of Micromonospora. 6108 A1 and C showed inhibitory activity against Gram-positive and some Gram-negative bacteria as potent as rosaramicin and exhibited low acute toxicity in mice. However, 6108 B showed less potent antimicrobial activity and 6108 D showed higher toxicity than those two antibiotics.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 43 (8), 938-947, 1990
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679122331008
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- NII Article ID
- 130003501867
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- COI
- 1:CAS:528:DyaK3MXjtVOr
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- ISSN
- 18811469
- 00218820
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed