New analogues of rosaramicin isolated from a Micromonospora strain

FUNAISHI KOHTAROU, KAWAMURA KENJI, SATOH FUMIO, HIRAMATSU MUNEYO, HAGIWARA MASAYUKI, OKANISH MASANORI

doi:10.7164/antibiotics.43.938

New analogues of rosaramicin isolated from a Micromonospora strain

DOI 被引用文献1件

FUNAISHI KOHTAROU

Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
KAWAMURA KENJI

Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
SATOH FUMIO

Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
HIRAMATSU MUNEYO

Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
HAGIWARA MASAYUKI

Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd.
OKANISH MASANORI

Exploratory Research Laboratory, Banyu Pharmaceutical Co., Ltd.

書誌事項

タイトル別名

New analogues of rosaramicin isolated from a Micromonospora strain. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

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説明

Antibiotics 6108 A₁, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A₄ and M-4365 A₁ from the cultured broth of strain BA06108 which was assigned to be a new species of Micromonospora. 6108 A₁ and C showed inhibitory activity against Gram-positive and some Gram-negative bacteria as potent as rosaramicin and exhibited low acute toxicity in mice. However, 6108 B showed less potent antimicrobial activity and 6108 D showed higher toxicity than those two antibiotics.