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- IMAHORI Kazutomo
- The University of Tokyo
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Alzheimer’s disease has been characterized by senile plaque and neurofibrillary tangle in the brain. However, their relation to etiology of this disease has been left unclear. Recently it has been clarified that neurofibrillay tangle consists of highly phosphorylated tau protein. Then we have started to identify the enzyme(s) responsible for this phosphorylation and obtained tau protein kinase I and II. Tau protein kinase I phosphorylated not only tau protein but also pyruvate dehydrogenase, phosphorylation of which caused inactivation of this enzyme and finally led the cell to death. Then we have proved that TPKI is upregulated in AD brain but not in control brain. Upregulation of TPKI was induced by treating the neuronal cells with Aβ protein. Finally we have identified oligomeric aggregation of Aβ protein named Amylospheroid is highly potent to degenerate neuronal cells both in vitro and in vivo systems.<br><br>(Communicated by Kunihiko SUZUKI, M.J.A.)
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 86 (1), 54-61, 2010
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390282679122355840
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- NII論文ID
- 130000149633
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 10547414
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可