Structure and function of <i>Helicobacter pylori</i> CagA, the first-identified bacterial protein involved in human cancer

DOI Web Site Web Site PubMed Research Data 12 Citations 168 References

Bibliographic Information

Other Title
  • Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer
  • Structure and function of Helicobacetr pylori CagA, the first-identified bacterial protein involved in human cancer

Search this article

Description

<p>Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial cells via bacterial type IV secretion, where it undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs. Delivered CagA then acts as a non-physiological scaffold/hub protein by interacting with multiple host signaling molecules, most notably the pro-oncogenic phosphatase SHP2 and the polarity-regulating kinase PAR1/MARK, in both tyrosine phosphorylation-dependent and -independent manners. CagA-mediated manipulation of intracellular signaling promotes neoplastic transformation of gastric epithelial cells. Transgenic expression of CagA in experimental animals has confirmed the oncogenic potential of the bacterial protein. Structural polymorphism of CagA influences its scaffold function, which may underlie the geographic difference in the incidence of gastric cancer. Since CagA is no longer required for the maintenance of established gastric cancer cells, studying the role of CagA during neoplastic transformation will provide an excellent opportunity to understand molecular processes underlying “Hit-and-Run” carcinogenesis.</p>

Journal

Citations (12)*help

See more

References(168)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top