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- MUKAIYAMA Teruaki
- The Kitasato Institute, Center for Basic Research
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- JONA Hideki
- The Kitasato Institute, Center for Basic Research Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
書誌事項
- タイトル別名
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- Glycosyl fluoride
- A superb glycosyl donor in glycosylation
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抄録
Catalytic and stereoselective glycosylations using glycosyl fluorides are described: 1) activation of armed glycosyl fluorides by trityl tetrakis(pentafluorophenyl)borate [TrB(C6F5)4] catalyst in trifluoromethylbenzene (BTF)-pivalonitrile ('BuCN)(5:1) to afford the corresponding disaccharides in high yields with good to high β-stereoselectivity; 2) activation of disarmed glycosyl fluorides by the combined use of silver tetrakis(pentafluorophenyl)borate [AgB(C6F5)4] and stannous chloride (SnCl2) or stannic chloride<br>(SnCl4); and 3) selective α or β glycosylation using glycosyl fluoride by an appropriate choice of erotic acid catalysts and solvents. Also, the effect of counter anions of erotic acid catalysts on controlling the stereo-selectivities of glycosylation is newly noted. Finally, efficient one-pot sequential syntheses of trisaccharide, F1α antigen, and branched heptasaccharide are demonstrated.
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 78 (4), 73-83, 2002
日本学士院
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679123548416
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- NII論文ID
- 130000907845
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 6179022
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可