- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Molecular approach to human leukemia: Isolation and characterization of the first human retrovirus HTLV-1 and its impact on tumorigenesis in Adult T-cell Leukemia
-
- YOSHIDA Mitsuaki
- Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
Search this article
Description
Molecular biology of mouse and chicken retroviruses had identified oncogenes and provided a revolutionary concept in understanding of cancers. A human retrovirus was established during 1980–1982 in linkage with a unique human leukemia, concurrently in Japan and USA. This review covers our efforts on the discovery of new retrovirus, Human T-cell Leukemia Virus Type 1 (HTLV-1), first introducing to a new class of retroviruses with a unique regulatory factors, Tax and Rex. Then it is followed by analyses of molecular interaction of the vial Tax with cellular machineries involved in the pathogenesis of Adult T-cell Leukemia (ATL). And then a probable mechanism of pathogenesis of ATL is proposed including recent findings on HBZ after our efforts.<br><br>(Communicated by Kumao TOYOSHIMA, M.J.A.)
Journal
-
- Proceedings of the Japan Academy, Series B
-
Proceedings of the Japan Academy, Series B 86 (2), 117-130, 2010
The Japan Academy
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679123662976
-
- NII Article ID
- 130000168768
-
- NII Book ID
- AA00785485
-
- ISSN
- 13492896
- 03862208
- http://id.crossref.org/issn/00214280
-
- NDL BIB ID
- 10547336
-
- PubMed
- 20154469
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
-
- Abstract License Flag
- Disallowed