Microbial metabolites with inhibitory activity against lipid metabolism

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  • TOMODA Hiroshi
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University
  • NAMATAME Ichiji
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University Japan Society for the Promotion of Science
  • OMURA Satoshi
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University

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Abstract

Microbial products inhibiting lipid metabolism, particularly involved in the fatty acid and cholesterol metabolic pathways were screened with various assay systems. Inhibitors were discovered for fatty acid synthase, acyl-coenzyme A (CoA) synthetase and diacylglycerol acyltransferase in fatty acid metabolism and 3-hydroxy-3-methylglutaryl-CoA synthase, acyl-CoA:cholesterol acyltransferase and cholesteryl ester transfer protein in cholesterol metabolism.

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