Microbial metabolites with inhibitory activity against lipid metabolism

  • TOMODA Hiroshi
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University
  • NAMATAME Ichiji
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University Japan Society for the Promotion of Science
  • OMURA Satoshi
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University

Search this article

Abstract

Microbial products inhibiting lipid metabolism, particularly involved in the fatty acid and cholesterol metabolic pathways were screened with various assay systems. Inhibitors were discovered for fatty acid synthase, acyl-coenzyme A (CoA) synthetase and diacylglycerol acyltransferase in fatty acid metabolism and 3-hydroxy-3-methylglutaryl-CoA synthase, acyl-CoA:cholesterol acyltransferase and cholesteryl ester transfer protein in cholesterol metabolism.

Journal

Citations (8)*help

See more

Details 詳細情報について

Report a problem

Back to top