Transthyretin-related familial amyloidotic polyneuropathy: progress in Kumamoto, Japan (1967-2010)
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- ARAKI Shukuro
- Kumamoto University
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- ANDO Yukio
- Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University
書誌事項
- タイトル別名
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- Transthyretin-related familial amyloidotic polyneuropathy—Progress in Kumamoto, Japan (1967–2010)—
- Transthyretin-related familial amyloidotic polyneuropathy—Progress in Kumamoto, Japan (1967–2010)—
- Transthyretin-related familial amyloidotic polyneuropath–Progress in Kumamoto, Japan (1967–2010)
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抄録
The authors reviewed contribution of Kumamoto University group to the progress of the studies on transthyretin (TTR)-related familial amyloidotic polyneuropathy (TTR-related FAP) for 42 years (from 1967 to 2009). Andrade (1952) first described a large group of patients with FAP in Portugal and Araki et al. (1967) in second discovered similar FAP patients in Arao, Kumamoto, Japan. Owing to progress in biochemical and molecular genetic analyses, FAP is now believed to occur worldwide. As of today, reports of about 100 different points of single or two mutations, or a deletion in the transthyretin (TTR) gene, have been published. The authors’ group has made pioneer works for study of FAP in the world. The focus on therapy in amylodosis will increase sharply as an impetus in near future, and successful treatments are expected.<BR><BR>(Communicated by Kumao TOYOSHIMA, M.J.A.)
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 86 (7), 694-706, 2010
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詳細情報 詳細情報について
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- CRID
- 1390282679124151808
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- NII論文ID
- 130000309238
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- HANDLE
- 2298/20426
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- NDL書誌ID
- 10779701
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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- CiNii Articles
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- 使用不可