Semaphorins and their receptors: Novel features of neural guidance molecules

  • KUMANOGOH Atsushi
    Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University World Premier International Immunology Frontier Research Center, Osaka University
  • KIKUTANI Hitoshi
    World Premier International Immunology Frontier Research Center, Osaka University Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University

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Semaphorins were originally identified as axon guidance cues involved in the development of the nervous system. In recent years, it is emerging that they also participate in various biological systems, including physiological and pathological processes. In this review, we primarily focus on our cumulative findings for the role of semaphorins and their receptors in the regulation of the immune system, while also summarizing recent progress in the context of cardiovascular system.<BR><BR>(Communicated by Takao SEKIYA, M.J.A.)

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