Conversion of brain cytosol profile from fetal to adult type during the perinatal period: Taurine-NAA exchange

DOI Web Site Web Site 被引用文献1件 参考文献38件

この論文をさがす

抄録

Mammals face drastic environmental changes at birth. Appropriate adjustments of various systems must take place rapidly to accommodate this once in a life time event. The brain undergoes significant adjustments as well, the most obvious of which is in its need to meet the drastic increase in energy consumption at the neuronal cell membrane due to the explosive increase in neural activities after birth. Actual changes were found to be taken place in two systems, namely, acid base balance control and cytosolic energy transport. The adjustments are accomplished by converting cytosol microenvironment from a taurine rich fetal type environment to an N-acetyl-aspartate (NAA) rich adult type environment during the post-natal period. High concentrations of taurine are necessary to provide effective buffering in the fetal brain, because the fetus cannot utilize the adult type of pCO2 dependent acid–base balance control system, namely respiration driven pCO2 changes. To accommodate the significantly higher demand of energy consumption at the membrane due to the increased neuronal activities, taurine has to be replaced by NAA, since the latter facilitates HEP transport from mitochondria to the membrane by passive diffusion.<BR><BR>(Communicated by Takashi SUGIMURA, M.J.A.)

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (38)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ