Microbial conversion of milbemycins: 30-oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei

NAKAGAWA KEIKO, TORIKATA AKIO, SATO KAZUO, TSUKAMOTO YOSHIHISA

doi:10.7164/antibiotics.43.1321

Microbial conversion of milbemycins: 30-oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei

DOI 被引用文献2件

NAKAGAWA KEIKO

Fermentation Research Laboratories, Sankyo Co., Ltd.
TORIKATA AKIO

Fermentation Research Laboratories, Sankyo Co., Ltd.
SATO KAZUO

Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.
TSUKAMOTO YOSHIHISA

Agricultural Chemicals Research Laboratories, Sankyo Co., Ltd.

書誌事項

タイトル別名

Microbial conversion of milvemycins: 30-Oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei.

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説明

Microorganisms were screened for their ability to modify milbemycin A₄ (la). Many strains, mostly actinomycetes and zygomycetes, were found to convert milbemycin A₄ (la) to one or more new products. Among these products, M-l, M-2, and M-3 were obtained using Amycolata autotrophica subsp. amethystina ATCC 35204, and were identified as 30-hydroxymilbemycin A₄ (1b), 26, 30-dihydroxymilbemycin A₄ (Ic), and milbemycin A₄ 30-oic acid (1d), respectively. Other milbemycins and LL-F28249α (7a) also underwent 30-hydroxylation by the microorganism. 22, 23-Dihydroavermectin B_1a (8a) was not hydroxylated at any position by A. autotrophica subsp. amethystina ATCC 35204, but a corresponding hydroxyl product at the C-30 position was obtained using Amycolatopsis mediterranei IFO 13415.