Comprehensive functional genomics using <i>Caenorhabditis elegans</i> as a model organism

DOI Web Site Web Site PubMed 1 Citations 46 References Open Access
  • MITANI Shohei
    Department of Physiology, Tokyo Women’s Medical University School of Medicine Tokyo Women’s Medical University Institute for Integrated Medical Sciences

Bibliographic Information

Other Title
  • Comprehensive functional genomics using Caenorhabditis elegans as a model organism

Search this article

Description

<p>We have been working on functional genomics using C. elegans as a model organism. We first used cell-type specific markers and preexisting mutants to investigate how genotype-phenotype causal relationships are regulated. With the aid of transgenic methods, we analyzed various biological processes in C. elegans. We have developed efficient methods to isolate gene knockout strains. Thousands of strains isolated this way are used by many researchers and have revealed many biological mechanisms. We have also developed methods to examine the functions of genes in a comprehensive manner by integrating transgenes into chromosomes, designing conditional knockouts, and creating balancers for lethal mutations. A combination of these biological resources and techniques will be useful to understand the functions of genes in C. elegans, which has many genes that are orthologous to those of higher organisms including humans.</p>

Journal

Citations (1)*help

See more

References(46)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top