Quaternary heterocyclylamino .BETA.-lactams. IV. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime.

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  • IV. COMPARISON OF THE <i>IN VIVO</i> ANTIBACTERIAL ACTIVITIES OF L-640, 876, MECILLINAM, CEFOXITIN AND CEFOTAXIME

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Description

The novel β-lactam, L-640, 876, exhibited excellent therapeutic activity when administered parenterally but not orally to mice infected with a variety of pathogenic bacteria. In this respect, the compound was as potent as cefotaxime against representative Gram-positive and Gram-negative organisms, in most cases, equal to or more potent than cefoxitin, and more effective than mecillinam. When administered subcutaneously to normal mice at dose levels ranging from 10 to 50 mg/kg, L-640, 876 provided an adequate dose response, recovery of ca. 45% of biological activity in the urine, and excellent distribution at the highest dose level into liver, lung, kidney, heart muscle, but not brain.

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Details 詳細情報について

  • CRID
    1390282679125136640
  • NII Article ID
    130003500333
  • DOI
    10.7164/antibiotics.36.64
  • ISSN
    18811469
    00218820
  • PubMed
    6088459
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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