Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

SUGAWARA KOKO, NISHIYAMA YUJI, TODA SOICHIRO, KOMIYAMA NOBUJIRO, HATORI MASAMI, MORIYAMA TOSHIO, SAWADA YOSUKE, KAMEI HIDEO, KONISHI MASATAKA, OKI TOSHIKAZU

doi:10.7164/antibiotics.45.1433

Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

DOI PubMed 被引用文献3件

SUGAWARA KOKO

Bristol-Myers Squibb Research Institute
NISHIYAMA YUJI

Bristol-Myers Squibb Research Institute
TODA SOICHIRO

Bristol-Myers Squibb Research Institute
KOMIYAMA NOBUJIRO

Bristol-Myers Squibb Research Institute
HATORI MASAMI

Bristol-Myers Squibb Research Institute
MORIYAMA TOSHIO

Bristol-Myers Squibb Research Institute
SAWADA YOSUKE

Bristol-Myers Squibb Research Institute
KAMEI HIDEO

Bristol-Myers Squibb Research Institute
KONISHI MASATAKA

Bristol-Myers Squibb Research Institute
OKI TOSHIKAZU

Bristol-Myers Squibb Research Institute

書誌事項

タイトル別名

PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

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説明

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.