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Cispentacin, A new antifungal antibiotic I. Production, isolation, physico-chemical properties and structure.
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- KONISHI MASATAKA
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
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- NISHIO MAKI
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
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- SAITOH KYOICHIRO
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
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- MIYAKI TAKEO
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
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- OKI TOSHIKAZU
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
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- KAWAGUCHI HIROSHI
- Bristol-Myers Research Institute, Ltd., Tokyo Research Center
Bibliographic Information
- Other Title
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- I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE
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Description
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R, 2S)-2-aminocyclopentane-l-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 42 (12), 1749-1755, 1989
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION