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EI-1941-1 and -2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941: I. Biochemical Characterization of EI-1941-1 and -2
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- KOIZUMI FUMITO
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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- MATSUDA YUZURU
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Corporate Planning Department, Kyowa Hakko Kogyo Co., Ltd.
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- NAKANISHI SATOSHI
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Strategic Planning Department, Pharmaceuticals Company, Kyowa Hakko Kogyo Co., Ltd.
Bibliographic Information
- Other Title
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- I. Biochemical Characterization of EI-1941-1 and-2
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Description
EI-1941-1 and -2 isolated from the culture broths of Farrowia sp. selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006μM, respectively, without inhibiting elastase and cathepsin B. EI-1941-1 and -2 also inhibited mature interleukin-1β secretion from THP-1 cells induced by LPS with IC50 values of 5.0 and 10.3μM, respectively. Biochemical characterizations of EI-1941-1 and-2 are described in this article.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 56 (5), 464-469, 2003
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION