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Poststatin, a New Inhibitor of Prolyl Endopeptidase. VI. Endopeptidase Inhibitory Activity of Poststatin Analogues Containing Pyrrolidine Ring.
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- TSUDA MAKOTO
- Institute of Microbial Chemistry
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- MURAOKA YASUHIKO
- Institute of Microbial Chemistry
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- SOMENO TETSUYA
- Research and Development Division, Pharmaceuticals Group, Nippon Kayaku Co., Ltd.
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- NAGAI MACHIKO
- Institute of Microbial Chemistry
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- AoYAGI TAKAAKI
- Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
Bibliographic Information
- Other Title
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- VI. Endopeptidase Inhibitory Activity of Poststatin Analogues Containing Pyrrolidine Ring
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Description
Several pyrrolidine-containing analogues of poststatin were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Replacement of the postine residue with 2-oxo-2-(2-pyrrolidinyl)acetic acid increased the selectivity and inhibitory activity against prolyl endopeptidase. Benzyloxycarbonyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl-D-phenylalanine was about 46 times as active to prolyl endopeptidase as natural poststatin.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 49 (9), 900-908, 1996
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679125305344
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- NII Article ID
- 130003503162
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- COI
- 1:CAS:528:DyaK28XlvFaiur8%3D
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- ISSN
- 18811469
- 00218820
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- PubMed
- 8931724
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed