TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp. Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties.

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  • KOHNO JUN
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • NISHIO MAKI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • KAWANO KIMIO
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • NAKANISHI NORIYUKI
    Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • SUZUKI SHIN-ICHI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • UCHIDA TOMOFUMI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • KOMATSUBARA SABURO
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.

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  • TMC-1 A B C and D New Antibiotics of th
  • Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties

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Abstract

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

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