Novel C-2 Substituted Carbapenem Derivatives. Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives.

BURTON GEORGE, CLEAR NICOLA J. C., EGLINGTON A. JOHN, GUEST ANGELA W., HUNT ERIC, NAYLOR ANTOINETTE, PEARSON MICHAEL J., TAKLE ANDREW K.

doi:10.7164/antibiotics.49.1258

Novel C-2 Substituted Carbapenem Derivatives. Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives.

DOI PubMed

BURTON GEORGE

SmithKline Beecham Pharmaceuticals
CLEAR NICOLA J. C.

SmithKline Beecham Pharmaceuticals
EGLINGTON A. JOHN

SmithKline Beecham Pharmaceuticals
GUEST ANGELA W.

SmithKline Beecham Pharmaceuticals
HUNT ERIC

SmithKline Beecham Pharmaceuticals
NAYLOR ANTOINETTE

SmithKline Beecham Pharmaceuticals
PEARSON MICHAEL J.

SmithKline Beecham Pharmaceuticals
TAKLE ANDREW K.

SmithKline Beecham Pharmaceuticals

書誌事項

タイトル別名

Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives

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CiNii Books

説明

A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.