Novel C-2 Substituted Carbapenem Derivatives. Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives.

DOI PubMed

Bibliographic Information

Other Title
  • Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives

Search this article

Description

A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390282679126095872
  • NII Article ID
    130003503073
  • DOI
    10.7164/antibiotics.49.1258
  • COI
    1:CAS:528:DyaK2sXhs1ClsA%3D%3D
  • ISSN
    18811469
    00218820
  • PubMed
    9031672
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top