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Novel C-2 Substituted Carbapenem Derivatives. Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives.
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- BURTON GEORGE
- SmithKline Beecham Pharmaceuticals
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- CLEAR NICOLA J. C.
- SmithKline Beecham Pharmaceuticals
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- EGLINGTON A. JOHN
- SmithKline Beecham Pharmaceuticals
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- GUEST ANGELA W.
- SmithKline Beecham Pharmaceuticals
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- HUNT ERIC
- SmithKline Beecham Pharmaceuticals
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- NAYLOR ANTOINETTE
- SmithKline Beecham Pharmaceuticals
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- PEARSON MICHAEL J.
- SmithKline Beecham Pharmaceuticals
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- TAKLE ANDREW K.
- SmithKline Beecham Pharmaceuticals
Bibliographic Information
- Other Title
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- Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives
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Description
A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 49 (12), 1258-1265, 1996
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679126095872
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- NII Article ID
- 130003503073
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- COI
- 1:CAS:528:DyaK2sXhs1ClsA%3D%3D
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- ISSN
- 18811469
- 00218820
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- PubMed
- 9031672
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed