Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora. 1. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological Properties.

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  • I. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological Properties

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Strain TP-A0121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36, C85H112O38, and C85H112O39 respectively.

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Details 詳細情報について

  • CRID
    1390282679126123904
  • NII Article ID
    130003503432
  • DOI
    10.7164/antibiotics.51.394
  • COI
    1:CAS:528:DyaK1cXivFOlsbY%3D
  • ISSN
    18811469
    00218820
    http://id.crossref.org/issn/00218820
  • PubMed
    9630861
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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