7-Hydro-8-methylpteroylglutamylglutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity.

MURATA MASATSUNE, TANAKA HARUO, OMURA SATOSHI

doi:10.7164/antibiotics.40.251

7-Hydro-8-methylpteroylglutamylglutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity.

DOI PubMed 被引用文献2件オープンアクセス

MURATA MASATSUNE

The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
TANAKA HARUO

The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
OMURA SATOSHI

The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University

書誌事項

タイトル別名

FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

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説明

A new anti-folate, 7-hydro-8-methylpteroylglutamylglutamic acid, was isolated from the culture broth of a soil actinomycete. The antibiotic inhibited the growth of Enterococcus faecium which requires folic acid. The inhibitory action was reversed by thymidine or excess amounts of folate-related compounds such as pteroic acid, folic acid, dihydrofolic acid and leucovorin. It inhibited thymidylate synthase from E. faecium, Bacillus subtilis and Ehrlich ascites carcinoma cells.