Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.

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Other Title
  • I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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Description

Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured broth of Streptomyces sp. MJ654-NF4. Though cytostatin did not inhibit EL-4 cell adhesion to ECM components such as laminin and fibronectin, it inhibited the adhesion of B16 melanoma cells to laminin and collagen type IV but not to fibronectin. It exhibited antimetastatic activity on B16 melanoma cells in mice. The cytotoxicity of cytostatin are also reported.

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Details 詳細情報について

  • CRID
    1390282679126385280
  • NII Article ID
    130003502757
  • DOI
    10.7164/antibiotics.47.536
  • COI
    1:CAS:528:DyaK2cXktlSltbo%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8040050
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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