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Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.
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- AMEMIYA MASAHIDE
- Institute for Chemotherapy, M. C. R. F.
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- UENO MITSUHIRO
- Institute for Chemotherapy, M. C. R. F.
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- OSONO MICHIYO
- Institute for Chemotherapy, M. C. R. F.
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- MASUDA TOHRU
- Institute for Chemotherapy, M. C. R. F.
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- KINOSHITA NAOKO
- Institute of Microbial Chemistry, M. C. R. F.
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- NISHIDA CHIGUSA
- Institute of Microbial Chemistry, M. C. R. F.
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- HAMADA MAWA
- Institute of Microbial Chemistry, M. C. R. F.
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- ISHIZUKA MASAAKI
- Institute for Chemotherapy, M. C. R. F.
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- TAKEUCHI OMIO
- Institute for Chemotherapy, M. C. R. F.
Bibliographic Information
- Other Title
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- I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES
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Description
Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured broth of Streptomyces sp. MJ654-NF4. Though cytostatin did not inhibit EL-4 cell adhesion to ECM components such as laminin and fibronectin, it inhibited the adhesion of B16 melanoma cells to laminin and collagen type IV but not to fibronectin. It exhibited antimetastatic activity on B16 melanoma cells in mice. The cytotoxicity of cytostatin are also reported.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 47 (5), 536-540, 1994
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
