5'-Nucleotidase inhibitory activity of nucleoticidin, melanocidin A and melanocidin B. Structure-activity relationships.
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- UCHINO KEIJIRO
- Department of Biochemistry, Meiji College of Pharmacy
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- AKIYAMA TETSU
- Department of Biochemistry, Meiji College of Pharmacy
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- FUKUCHI AKIRA
- Central Laboratory , Nippon Flour Mills Co., Ltd.
書誌事項
- タイトル別名
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- STRUCTURE-ACTIVITY RELATIONSHIPS
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説明
Nucleoticidin and melanocidins A and B exhibited potent inhibitory activity against 5'-nucleotidases from rat liver membrane and snake venom. These inhibitors are polysaccharides with highly branched side chains having at least disaccharide units. This conclusion was supported by the results with polysaccharides of known chemical structures. The inhibitors showed non-competitive inhibition with respect to AMP, and urea-treatment caused a marked decrease or a disappearance of the 5'-nucleotidase inhibitory activity. Therefore, it is concluded that steric factors also play an important role in their inhibitory activity.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 38 (11), 1564-1567, 1985
公益財団法人 日本感染症医薬品協会