5'-Nucleotidase inhibitory activity of nucleoticidin, melanocidin A and melanocidin B. Structure-activity relationships.

書誌事項

タイトル別名
  • STRUCTURE-ACTIVITY RELATIONSHIPS

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説明

Nucleoticidin and melanocidins A and B exhibited potent inhibitory activity against 5'-nucleotidases from rat liver membrane and snake venom. These inhibitors are polysaccharides with highly branched side chains having at least disaccharide units. This conclusion was supported by the results with polysaccharides of known chemical structures. The inhibitors showed non-competitive inhibition with respect to AMP, and urea-treatment caused a marked decrease or a disappearance of the 5'-nucleotidase inhibitory activity. Therefore, it is concluded that steric factors also play an important role in their inhibitory activity.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 38 (11), 1564-1567, 1985

    公益財団法人 日本感染症医薬品協会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679126669568
  • NII論文ID
    130003500799
  • DOI
    10.7164/antibiotics.38.1564
  • ISSN
    18811469
    00218820
  • PubMed
    3001014
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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