Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities.

MOMOSE ISAO, CHEN WEI, KINOSHITA NAOKO, IINUMA HIRONOBU, HAMADA MASA, TAKEUCHI TOMIO

doi:10.7164/antibiotics.51.21

Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities.

DOI PubMed 被引用文献1件

MOMOSE ISAO

Institute of Microbial Chemistry
CHEN WEI

Institute of Microbial Chemistry
KINOSHITA NAOKO

Institute of Microbial Chemistry
IINUMA HIRONOBU

Institute of Microbial Chemistry
HAMADA MASA

Institute of Microbial Chemistry
TAKEUCHI TOMIO

Institute of Microbial Chemistry

書誌事項

タイトル別名

I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities

この論文をさがす

CiNii Books

説明

A new antibiotic designated polyketomycin was isolated from the culture broth of Streptomyces sp. MK277-AF1. It was purified by ethyl acetate extraction, Sephadex LH-20 column chromatography and centrifugal partition chromatography (CPC). It inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Its MICs were less than 0.2μg/ml. Polyketomycin exhibited cytotoxic activity against nine tumor cell lines at concentrations of 0.9∼5.2μg/ml.