Deepoxidation of 16-membered epoxyenone macrolide antibiotics. I. Microbial deepoxidation and subsequent isomerization of deltamycins A1, A2, A3, A4 (carbomycin A) and X.

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  • I. MICROBIAL DEEPOXIDATION AND SUBSEQUENT ISOMERIZATION OF DELTAMYCINS A<sub>1</sub>, A<sub>2</sub>, A<sub>3</sub>, A<sub>4</sub> (CARBOMYCIN A) AND X

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Carbomycin A (deltamycin A4) was deepoxidized to carbomycin A P1 by Streptomyces halstedii subsp. deltae (a deltamycins producer), favorably under anaerobic conditions. Carbomycin A P1 was spontaneously converted to geometric isomers designated carbomycins A P2 and A P3. This type of deepoxidation and subsequent isomerization was not limited to carbomycin A, but generally occurrable in other 16-membered epoxyenone macrolide compounds. Many bacteria and actinomycetes were also found to have an ability to deepoxidize deltamycins reductively. The chemical structures of carbomycins A P1, A P2 and A P3 were elucidated as shown in Fig. 3.

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Details 詳細情報について

  • CRID
    1390282679127166848
  • NII Article ID
    130003409454
  • DOI
    10.7164/antibiotics.37.118
  • COI
    1:CAS:528:DyaL2cXitVKhtbk%3D
  • ISSN
    18811469
    00218820
  • PubMed
    6706847
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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