Deepoxidation of 16-membered epoxyenone macrolide antibiotics. I. Microbial deepoxidation and subsequent isomerization of deltamycins A1, A2, A3, A4 (carbomycin A) and X.
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- FUKAGAWA YASUO
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
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- MUTOH YOSHIFUMI
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
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- ISHIKURA TOMOYUKI
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
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- LEIN JOSEPH
- Panlabs, Inc.
書誌事項
- タイトル別名
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- I. MICROBIAL DEEPOXIDATION AND SUBSEQUENT ISOMERIZATION OF DELTAMYCINS A<sub>1</sub>, A<sub>2</sub>, A<sub>3</sub>, A<sub>4</sub> (CARBOMYCIN A) AND X
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説明
Carbomycin A (deltamycin A4) was deepoxidized to carbomycin A P1 by Streptomyces halstedii subsp. deltae (a deltamycins producer), favorably under anaerobic conditions. Carbomycin A P1 was spontaneously converted to geometric isomers designated carbomycins A P2 and A P3. This type of deepoxidation and subsequent isomerization was not limited to carbomycin A, but generally occurrable in other 16-membered epoxyenone macrolide compounds. Many bacteria and actinomycetes were also found to have an ability to deepoxidize deltamycins reductively. The chemical structures of carbomycins A P1, A P2 and A P3 were elucidated as shown in Fig. 3.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 37 (2), 118-126, 1984
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