Antitumor protective property of an isoprenoid antibiotic, ascofuranone.
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- MAGAE JUNJI
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- HOSOKAWA TOMOYOSHI
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- ANDO KUNIO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- NAGAI KAZUO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- TAMURA GAKUZO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
Bibliographic Information
- Other Title
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- Antitumor Protective Property of an Iso
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Abstract
Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered once daily for 5 consecutive days 24 hours after transplantation, but antitumor effect was not seen with combined treatments before and after the transplantation. Similar results were noted with Ehrlich ascites carcinoma. AF treatment of normal mice enlarged the solid lymphoid organs without affecting body weight gain. The splenocytes derived from AF-treated mice lowered mitogenic response to phytohemagglutinin, while the mitogenic response to concanavalin A and lipopolysaccharide was unaffected.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 35 (11), 1547-1552, 1982
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Details 詳細情報について
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- CRID
- 1390282679127242752
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- NII Article ID
- 130003500169
- 40005315256
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaL3sXislCmsQ%3D%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 2617089
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- PubMed
- 7161193
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed