Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
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- SAWA RYUICHI
- Institute of Microbial Chemistry
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- TAKAHASHI YOSHIKAZU
- Institute of Microbial Chemistry
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- ITOH SAKIKO
- Institute of Microbial Chemistry
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- SHIMANAKA KAZUO
- Institute of Microbial Chemistry
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- KINOSHITA NAOKO
- Institute of Microbial Chemistry
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- HOMMA YOSHIKO
- Institute of Microbial Chemistry
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- HAMADA MASA
- Institute of Microbial Chemistry
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- SAWA TSUTOMU
- Institute of Microbial Chemistry
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- NAGANAWA HIROSHI
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
Bibliographic Information
- Other Title
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- I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
Description
A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The 1H and 13C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 47 (11), 1266-1272, 1994
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION