New Cineromycins and Musacins Obtained by Metabolite Pattern Analysis of Streptomyces griseoviridis FH-S 1832). II. Structure Elucidation.

SCHNEIDER ANDREA, SPÄTH JULIA, BREIDING-MACK SABINE, ZEECK AXEL, GRABLEY SUSANNE, THIERICKE RALF

doi:10.7164/antibiotics.49.438

New Cineromycins and Musacins Obtained by Metabolite Pattern Analysis of Streptomyces griseoviridis FH-S 1832). II. Structure Elucidation.

DOI PubMed 被引用文献2件

SCHNEIDER ANDREA

Institut für Organische Chemie, Universität Göttingen
SPÄTH JULIA

Institut für Organische Chemie, Universität Göttingen
BREIDING-MACK SABINE

Institut für Organische Chemie, Universität Göttingen
ZEECK AXEL

Institut für Organische Chemie, Universität Göttingen
GRABLEY SUSANNE

Hans-Knöll-Institut für Naturstoff-Forschung e.V.
THIERICKE RALF

Hans-Knöll-Institut für Naturstoff-Forschung e.V.

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タイトル別名

II. Structure Elucidation

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説明

A detailed analysis of the secondary metabolite pattern produced by Streptomyces griseoviridis (strain FH-S 1832) using a chemical screening method resulted in the detection, isolation and structure elucidation of new 14-membered lactones of the cineromycin B-type [dehydrocineromycin B (5), oxycineromycin B (7), and 2, 3-dihydrocineromycin B (8)], as well as new γ-lactones related to nigrosporalactone and 4, 5-dihydroxy-octa-2, 6-dienoic acid esters named musacins A to F (10, 13-15, 17, 18 and 21). The constitution of these metabolites were deduced from spectroscopic data as well as chemical transformations. The configuration of musacin D (10) was determined by derivatization with chiral acids (Helmchen's method).