Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov.. III. Structural determination of mycoplanecin A.
-
- NAKAJIMA MUTSUO
- Fermentation Research Laboratories, Sankyo Co., Ltd.
-
- TORIKATA AKIO
- Fermentation Research Laboratories, Sankyo Co., Ltd.
-
- TAMAOKI HIDETSUNE
- Fermentation Research Laboratories, Sankyo Co., Ltd.
-
- HANEISHI TATSUO
- Fermentation Research Laboratories, Sankyo Co., Ltd.
-
- ARAI MAMORU
- Fermentation Research Laboratories, Sankyo Co., Ltd.
-
- KINOSHITA TAKESHI
- Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
-
- KUWANO HARUMITSU
- Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
書誌事項
- タイトル別名
-
- III. STRUCTURAL DETERMINATION OF MYCOPLANECIN A
抄録
The structure of mycoplanecin A was determined by the analysis of chemical degradation products and by mass and 1H and 13C NMR spectrometries. Mycoplanecin A is a new cyclic peptide antibiotic composed of mol each of α-ketobutyric acid, glycine, L-leucine, L-proline, L-2-amino-5-methylhexanoic acid, N-methyl-D-leucine, N-methyl-L-threonine, methyl-L-proline and ethyl-L-proline and two mol of N-methyl-L-valine. Among these components, ethyl-L-proline is reported for the first time as a component of natural products. A newly developed mass analysis has been introduced for the differentiation of α-amino acid and its N-methyl derivative.
収録刊行物
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 36 (8), 967-975, 1983
公益財団法人 日本感染症医薬品協会