UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity.

  • UOSAKI YOUICHI
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • KAWADA SHO-ZOU
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Technical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • NAKANO HIROFUMI
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • SAITOH YUTAKA
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
  • SANO HIROSHI
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Shimizu Institute, Marine Biotechnology Institute Co., Ltd.

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Other Title
  • STRUCTURE DETERMINATION

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Description

The relative stereo structure of UCT4B was determined by means of chemical derivatization and spectral analysis, in relation to known antitumor antibiotics terpentecin, which was simultaneously produced with UCT4B by Streptomyces sp.

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Details 詳細情報について

  • CRID
    1390282679127687936
  • NII Article ID
    130003502464
  • DOI
    10.7164/antibiotics.46.235
  • COI
    1:CAS:528:DyaK3sXktVymtL8%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8385658
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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