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UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity.
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- UOSAKI YOUICHI
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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- KAWADA SHO-ZOU
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Technical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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- NAKANO HIROFUMI
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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- SAITOH YUTAKA
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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- SANO HIROSHI
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Shimizu Institute, Marine Biotechnology Institute Co., Ltd.
Bibliographic Information
- Other Title
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- STRUCTURE DETERMINATION
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Description
The relative stereo structure of UCT4B was determined by means of chemical derivatization and spectral analysis, in relation to known antitumor antibiotics terpentecin, which was simultaneously produced with UCT4B by Streptomyces sp.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (2), 235-240, 1993
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION