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- KIYOTO SUMIO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KAWAI YOSHIO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KAWAKITA TAKESHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KING EIKO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- OKUHARA MASAKUNI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- UCHIDA ITSUO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- TANAKA HIROKAZU
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- HASHIMOTO MASASHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- TERANO HIROSHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KOHSAKA MASANOBU
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- AOKI HATSUO
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- IMANAKA HIROSHI
- Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd. Planning and Development Group, Fujisawa Pharmaceutical Co., Ltd.
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Description
A complex of the new antitumor antibiotics (WF-1360, WF-1360A, B, C, D, E and F) was produced by Rhizopus sp. No. F-1360. Structural studies of these compounds suggested that they were novel 16-membered-ring lactones having an oxazole ring in their structures. WF-1360 was found to be identical with rhizoxin (1) and WF-1360B, C, E and F were de-termined to be homologues of 1 with structures 2, 3, 4 and 5, respectively. These compounds were cytotoxic when tested on P388 leukemia cells in vitro. WF-1360 was highly active against leukemia L1210 and melanoma B16. They also exhibited potent antifungal activities, but weak antimicrobial activities against some Gram-positive or negative bacteria.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 39 (6), 762-772, 1986
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION