Bequinostatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
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- AOYAMA TAKAYUKI
- Institute of Microbial Chemistry
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- KOJIMA FUKIKO
- Institute of Microbial Chemistry
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- ABE FUMINORI
- Research Laboratories of Nippon Kayaku Co., Ltd.
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- MURAOKA YASUHIKO
- Institute of Microbial Chemistry
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- NAGANAWA HIROSHI
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
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- AOYAGI TAKAAKI
- Showa College of Pharmaceutical Sciences
書誌事項
- タイトル別名
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- PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES
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説明
New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5, 6, 8, 13-tetrahydro-1, 6, 7, 9, 11-pentahydroxy-8, 13-dioxo-3-pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinostatin A, respectively. Bequinostatin A showed considerable inhibitory activity against human pi class glutathione S-transferase (GST π).
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (6), 914-920, 1993
公益財団法人 日本感染症医薬品協会
