Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D. II. Structure Elucidation.
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- ISHIYAMA DAISUKE
- Metabolism Research, Kaken Pharmaceutical CO., LTD.
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- KANAI YOSHINORI
- Institute of Biotechnology Applied to Soil Eumycetes
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- SENDA HISATO
- Metabolism Research, Kaken Pharmaceutical CO., LTD.
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- IWATANI WAKAO
- Metabolism Research, Kaken Pharmaceutical CO., LTD.
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- TAKAHASHI HIROKO
- Institute of Biotechnology Applied to Soil Eumycetes
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- KONNO HIROSHI
- Institute of Biotechnology Applied to Soil Eumycetes
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- KANAZAWA SUSUMU
- Institute of Biotechnology Applied to Soil Eumycetes
書誌事項
- タイトル別名
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- II. Structure Elucidation
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説明
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 53 (9), 873-878, 2000
公益財団法人 日本感染症医薬品協会