Erabulenols, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Penicillium sp. FO-5637. II. Structure Elucidation of Erabulenols A and B.
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- TABATA NORIKO
- Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University
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- TOMODA HIROSHI
- Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University
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- OMURA SATOSHI
- Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University
書誌事項
- タイトル別名
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- II. Structure Elucidation of Erabulenols A and B
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説明
Structures of erabulenols A and B, novel fungal inhibitors of cholesteryl ester transfer protein were elucidated by spectroscopic studies including various NMR measurements. Erabulenols consist of a phenalenone skeleton and a 1, 2, 2-trimethyltetrahydrofuran moiety in common. Erabulenol B possesses an additional 2, 6-dihydroxy-5-methyl-3-methylketonyl benzyl moiety. The absolute stereochemistry at the C-2′ position of erabulenol A was deduced as S by comparison of the optical rotation with that of other related compounds.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 51 (7), 624-628, 1998
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