Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649. I Taxonomy, Fermentation, Isolation and Biological Activities.

DOI PubMed Open Access
  • HAYASHI MASAHIKO
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • KIM YONG-PIL
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • TAKAMATSU SATOSHI
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • PREEPRAME SRISOMPORN
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • KOMIYA TAKAMARO
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • MASUMA ROKURO
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • TANAKA HARUO
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • KOMIYAMA KANKI
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University
  • OMURA SATOSHI
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University

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Other Title
  • I. Taxonomy, Fermentation, Isolation and Biological Activities

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Description

Selective growth inhibition against IL-6 dependent cells was detected in fermentation extracts of a fungal strain FO-4649 which was characterized as Sporothrix species. An active metabolite (1) termed chlovalicin was isolated together with ovalicin and two other ovalicin derivatives (compounds 3 and 4). Chlovalicin, a ovalicin derivative with a chlorinated methylene moiety at the C-1 position of the cyclohexane ring, dose-dependently inhibited the growth of IL-6 dependent MH60 cells (IC50, 7.5μM) in the presence of 0.2U/ml IL-6 and, to a lesser extent, the growth of B16 melanoma cells (IC50, 38μM). Among the other three compounds, only ovalicin showed inhibitory activity (IC50, 27μM) against MH60 cells. These four compounds did not show any antimicrobial activity at a concentration of 1000 μg/ml.

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Details 詳細情報について

  • CRID
    1390282679128317056
  • NII Article ID
    130003503134
  • DOI
    10.7164/antibiotics.49.631
  • COI
    1:CAS:528:DyaK28Xks1eqsL4%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8784421
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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