Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex.
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- KANAI FUMIAKI
- Institute of Microbial Chemistry
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- KANEKO TOSHIKO
- Institute of Microbial Chemistry
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- MORISHIMA HAJIME
- Institute of Microbial Chemistry
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- ISSHIKI KUNIO
- Institute of Microbial Chemistry
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- TAKITA TOMOHISA
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- III. INHIBITION OF THYMIDYLATE SYNTHETASE BY VANOXONIN-VANADIUM COMPLEX
説明
Quinquevalent vanadium complex with two mol of vanoxonin ligated by the two catechols was shown to be the active structure for inhibition of thymidylate synthetase. The catechol group of vanoxonin as the essential moiety for the inhibition of enzyme was further confirmed by studies of structure-activity relationships using the enzyme obtained from Ehrlich ascites carcinoma cells of mice. Vanoxonin-vanadium complex showed competitive inhibition with respect to deoxyuridylic acid but uncompetitive to 5, 10-methylenetetrahydrofolate.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 38 (1), 39-50, 1985
公益財団法人 日本感染症医薬品協会
