Synergism of PS-5 with penicillins and cephalosporins in antimicrobial activity against .BETA.-lactam-resistant gram-negative microorganisms.
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- SAKAMOTO MICHIKO
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
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- ISHIKURA TOMOYUKI
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
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- FUKAGAWA YASUO
- Sanraku-Ocean Co., Ltd., Central Research Laboratories
抄録
The in vitro synergism or PS-5 combined with various penicinins and cephalosporins in antimicrobial activity was examined in detail against β-lactam-resistant Gram-negative bacteria. PS-5 showed a highly significant synergism in antimicrobial action against Escherichia coli RGN238 in combination with penicinins; and against Proteus vulgaris GN76 and Serratia marcescens T55 in combination with cephalosporins. It was moderately synergistic against Citrobacter freundii GN346, Enterobacter cloacae 45, Proteus morganii 111 and Enterobacter aerogenes E19, whereas no synergism was observed against Pseudomonas aeruginosa E2 and Klebsiella pneumoniae. 130
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 37 (11), 1414-1422, 1984
公益財団法人 日本感染症医薬品協会