Chemical modification of carbapenem antibiotics. Versatile methods for displacement of the C-3 sulfur side chain of carbapenems with other thiol groups.

DOI Web Site PubMed

Bibliographic Information

Other Title
  • Chemical Modification of Carbapenem Ant
  • VERSATILE METHODS FOR DISPLACEMENT OF THE C-3 SULFUR SIDE CHAIN OF CARBAPENEMS WITH OTHER THIOL GROUPS

Search this article

Description

Carbapenem derivatives substituted at the C-3 position were synthesized (1) by treating carbapenem S-oxides with various mercaptans in the presence of a base (Fig. 3), or (2) by alkylating or acylating 3-thiol carbapenems (Fig. 4).

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top