FUNICULOSIN, A NEW ANTIBIOTIC. I ISOLATION, BIOLOGICAL AND CHEMICAL PROPERTIES

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  • ANDO KUNIO
    Laboratory of Microbiology, Department of Agricultural Chemistry, the University of Tokyo
  • SUZUKI SEIKICHI
    Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • SAEKI TETSUJI
    Laboratory of Microbiology, Department of Agricultural Chemistry, the University of Tokyo
  • TAMURA GAKUZO
    Laboratory of Microbiology, Department of Agricultural Chemistry, the University of Tokyo
  • ARIMA KEI
    Laboratory of Microbiology, Department of Agricultural Chemistry, the University of Tokyo

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  • Funiculosin,a new antibiotic-1-Isolation,biological and chemical properties(Studies on antiviral and antitumor antibiotics.-13-)
  • Funiculosin, a new antibiotic. I. Isolation, biological and chemical properties (studies on antiviral and antitumor antibiotics. 8)
  • Studies on Antiviral and Antitumor Antibiotics. XIII

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Abstract

A new antibiotic, funiculosin, C27H41NO7, was isolated from the filter cake of the fermented broth of Penicillium funiculosum THOM. Funiculosin is a neutral lipophilic substance which inhibits both DNA and RNA viruses as tested in infected primary chick embryo fibroblast cell monolayer and also some pathogenic fungi such as Tricophyton mentagrophytes and Candida albicans.

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