ASCOCHLORIN, A NEW ANTIBIOTIC, FOUND BY PAPER-DISC AGAR-DIFFUSION METHOD. I

DOI PubMed 16 Citations Open Access
  • TAMURA GAKUZO
    Department of Agricultural Chemistry, the University of Tokyo
  • SUZUKI SEIKICHI
    Department of Agricultural Chemistry, the University of Tokyo Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • TAKATSUKI AKIRA
    Department of Agricultural Chemistry, the University of Tokyo
  • ANDO KUNIO
    Department of Agricultural Chemistry, the University of Tokyo
  • ARIMA KEI
    Department of Agricultural Chemistry, the University of Tokyo

Bibliographic Information

Other Title
  • Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I).
  • Ascochlorin, a new antibiotic, found by paper-disc agar-diffusion method. I isolation, biological and chemical properties of ascochlorin (studies on antiviral and antitumor antibiotics. 1)
  • ISOLATION, BIOLOGICAL AND CHEMICAL PROPERTIES OF ASCOCHLORIN (STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. I)

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Description

A new antibiotic, ascochlorin, C23H29O4Cl, was obtained from the filter cake of the fermented broth of Ascochyta viciae LIBERT. Ascochlorin inhibits plaque formation of both DNA and RNA viruses in the agar-diffusion plaque inhibition method. However, it showed no antiviral activity by the tube culture method. It showed cytotoxicity to chick embryo fibroblast monolayer and HeLa cells at a concentration of 0.3 meg/ml in tube culture. The anti biotic was obtained in two forms, the physical and chemical properties of which are described.

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Details 詳細情報について

  • CRID
    1390282679129508992
  • NII Article ID
    130003408711
  • DOI
    10.7164/antibiotics.21.539
  • COI
    1:CAS:528:DyaF1MXislCkuw%3D%3D
  • ISSN
    18811469
    00218820
    http://id.crossref.org/issn/00218820
  • PubMed
    4304615
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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