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- NISHIDA MINORU
- Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- MINE YASUHIRO
- Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- KUWAHARA SHOGO
- Department of Microbiology, Toho University School of Medicine
Bibliographic Information
- Other Title
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- Synergistic activity of ampicillin and cloxacillin;Protective effect of cloxacillin on enzymatic degradation of ampicillin by penicillinase,and therapeutic activity of mixtures of ampicillin and cloxacillin
- PROTECTIVE EFFECT OF CLOXACILLIN ON ENZYMATIC DEGRADATION OF AMPICILLIN BY PENICILLINASE, AND THERAPEUTIC ACTIVITY OF MIXTURES OF AMPICILLIN AND CLOXACILLIN
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Abstract
A mixture of ampicillin (aminobenzyl penicillin, AB-PC) and cloxacillin (methylchlorophenylisoxazolyl penicillin, MCI-PC) showed an excellent bactericidal activity even at low concentrations in which either of the penicillins alone did not have any activity against a clinically isolated strain of Escherichia coli, resistant to both of these penicillins. In this case, the microbial degradation of AB-PC, caused by penicillinase (PC-ase), was strongly inhibited in the presence of MCI-PC. The enzymatic hydrolysis of AB-PC by extracellular and cell-bound PC-ase, obtained from an AB-PC resistant strain of Staphylococcus aureus, was also inhibited in the presence of MCI-PC. Against that, under comparable conditions, penicillin G (PC-G) was almost completely destroyed by cell-bound PC-ase from this organism. An in vivo synergism was observed when mixtures of AB-PC and MCI-PC were applied for the treatment of mice challenged with a clinically isolated strain of E. coli resistant to both of these penicillins. Similar results were obtained in the treatment of mice experimentally infected with a strain of Staphylococcus aureus, which is highly resistant to AB-PC, but sensitive to MCI-PC.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 22 (4), 144-150, 1969
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679129581696
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- NII Article ID
- 130003498170
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXkt1Sltbo%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 8510031
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- PubMed
- 4895357
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed