Adsorption of 99mTc Labeled HMDP and MDP on Hydroxyapatite.

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  • YOSHINO Tomio
    School of Medical Sciences, The University of Tokushima
  • MIYOSHI Hirokazu
    School of Medical Sciences, The University of Tokushima
  • KISHI Taro
    University Hospital, School of Medicine, The University of Tokushima
  • SATOU Kazuo
    University Hospital, School of Medicine, The University of Tokushima
  • MATUMOTO Takahiro
    University Hospital, School of Medicine, The University of Tokushima

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Other Title
  • ｀９９ｍ´Ｔｃ標識ＨＭＤＰおよびＭＤＰのヒドロキシアパタイトへの吸着
  • 99m Tc ヒョウシキ HMDP オヨビ MDP ノ ヒドロキシアパタイト

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Abstract

The in vitro adsorption on hydroxyapatite (HAP) of 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) and 99mTc-methylene diphosphonate (99mTc-MDP), which are used as bone imaging agents, was studied. The adsorption of both diphosphonates was carried out in the concentration of 1.2×10-5 and 4.7×10-5 mol/dm3. Radioactivities of the filtrate and precipitate taken from the adsorptive solution were measured, and the filtrate was analyzed with radio-thinlayer chromatography. The 99mTc compounds forming polymers, as previously reported, were remained partially on the precipitate paper at the initial stage of adsorption. The amount of 99mTc-HMDP and MDP adsorbed for 1 h was 84% and 77%, respectively, the former adsorbed on HAP to a greater degree than did the latter. The compounds adsorbed on HAP are in a state of adsorption equilibrium with those in the solutions even after adsorbing for 3 h, and seem to be stable.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 43 (10), 609-612, 1994

    Japan Radioisotope Association

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