Studies on bredinin. I. Isolation, characterization and biological properties.

DOI PubMed 21 Citations

Bibliographic Information

Other Title
  • Studies on bredinin: Isolation, characterization and biological properties
  • ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

Description

Bredinin, C9H13N3O6, is, a novel imidazole nucleoside with an immunosbppressive activity. It was isolated from the culture filtrate of Eupenicillium brefeldianum M-2166 by means of ion-exchange or partition chromatography. Bredinin shows selective cytotoxicity against L5178Y cells derived from malignant lymphoma of the mouse. As an immunosuppressant, it has favorable characteristics, namely, a potent activity, low acute toxicity, and a slight effect on a decrease of peripheral leukocytes. Bredinin inhibits the growth of vaccinia virus but not that of bacteria or fungi except for Candida albicans in vitro.<br>Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.

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Details 詳細情報について

  • CRID
    1390282679130163584
  • NII Article ID
    130003498766
  • DOI
    10.7164/antibiotics.27.775
  • COI
    1:CAS:528:DyaE2MXhtlOltLo%3D
  • ISSN
    18811469
    00218820
    http://id.crossref.org/issn/00218820
  • PubMed
    4616933
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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