Chemical studies on tuberactinomycin. VIII. Isolation of tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, and conversion of tuberactinomycin N to O.
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- WAKAMIYA TATEAKI
- Department of Chemistry, Faculty of Science, Osaka University
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- SHIBA TETSUO
- Department of Chemistry, Faculty of Science, Osaka University
書誌事項
- タイトル別名
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- ISOLATION OF TUBERACTINAMINE N, THE CYCLIC PEPTIDE MOIETY OF TUBERACTINOMYCIN N, AND CONVERSION OF TUBERACTINOMYCIN N TO O
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説明
Tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, was obtained in a crystalline state through liberation of γ-hydroxy-β-lysine from tuberactinomycin N by acid treatment. Tuberactinamine N possesses an intramolecular hydrogen bond in its molecule and showed antibacterial activities comparable to those of the original antibiotics. Conversion of tuberactinomycin N to O was achieved through coupling of diacyl-β-lysine with tuberactinamine N followed by removal of the protecting groups.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 28 (4), 292-297, 1975
公益財団法人 日本感染症医薬品協会