Chemical studies on tuberactinomycin. VIII. Isolation of tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, and conversion of tuberactinomycin N to O.

WAKAMIYA TATEAKI, SHIBA TETSUO

doi:10.7164/antibiotics.28.292

Chemical studies on tuberactinomycin. VIII. Isolation of tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, and conversion of tuberactinomycin N to O.

DOI PubMed 被引用文献5件

WAKAMIYA TATEAKI

Department of Chemistry, Faculty of Science, Osaka University
SHIBA TETSUO

Department of Chemistry, Faculty of Science, Osaka University

書誌事項

タイトル別名

ISOLATION OF TUBERACTINAMINE N, THE CYCLIC PEPTIDE MOIETY OF TUBERACTINOMYCIN N, AND CONVERSION OF TUBERACTINOMYCIN N TO O

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説明

Tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, was obtained in a crystalline state through liberation of γ-hydroxy-β-lysine from tuberactinomycin N by acid treatment. Tuberactinamine N possesses an intramolecular hydrogen bond in its molecule and showed antibacterial activities comparable to those of the original antibiotics. Conversion of tuberactinomycin N to O was achieved through coupling of diacyl-β-lysine with tuberactinamine N followed by removal of the protecting groups.