.BETA.-Lactam antibiotics. I. Comparative structure-activity relationships of 6-acylaminopenicillanic acid derivatives and their 6-(D-.ALPHA.-acylaminophenylacetamido) penicillanic acid analogues.

FERRES HARRY, BASKER MICHAEL J., O''HANLON PETER J.

doi:10.7164/antibiotics.27.922

.BETA.-Lactam antibiotics. I. Comparative structure-activity relationships of 6-acylaminopenicillanic acid derivatives and their 6-(D-.ALPHA.-acylaminophenylacetamido) penicillanic acid analogues.

DOI PubMed 被引用文献1件

FERRES HARRY

Beecham Research Laboratories, Brockham Park
BASKER MICHAEL J.

Beecham Research Laboratories, Brockham Park
O''HANLON PETER J.

Beecham Research Laboratories, Brockham Park

書誌事項

タイトル別名

COMPARATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF 6-ACYLAMINOPENICILLANIC ACID DERIVATIVES AND THEIR 6-(D-α-ACYLAMINOPHENYLACETAMIDO) PENICILLANIC ACID ANALOGUES

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説明

Structure-activity relationships were compared for two series of penicillins containing a common acyl group. In series I, which included most of the penicillins in clinical use, the acyl moiety was linked directly to the amino group of the penicillin nucleus. For series II the acyl moiety was linked to the amino group of D-α-aminobenzylpenicillin (ampicillin). In the majority of cases a striking similarity between the two series was observed. The correlation provided both a valuable means of classifying and predicting the antibacterial properties of one series from a knowledge of the other.