Isolation of three new antibiotics,thiocillins 1,2 and 3,related to micrococcin P(Studies on antibiotics from the genus Bacillus-8-)

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  • Studies on antibiotics from the genus Bacillus. VIII. Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P.
  • Isolation of three new antibiotics thio
  • STUDIES ON ANTIBIOTICS FROM THE GENUS <i>BACILLUS</i>. VIII

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Thiocillins I and It were isolated from the culture broth of Bacillus cereus G-15, and thiocillins II and III from that of Bacillus badius AR-91. Also, the former two were probably produced by Bacillus megatherium I-13. These antibiotics active against Gram-positive bacteria are soluble in a mixture of chloroform and methanol, show characteristic ultraviolet absorptions (maxima at ca. 275 nm and ca. 348 nm), and contain a high content of sulfur, as much as approximately 15%. They are related to each other and also to micrococcin P, but differentiated by chromatographic behaviours.

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