BIOLOGICAL CHARACTERIZATION OF DIUMYCIN, A PHOSPHORUS-CONTAINING GLYCOLIPID ANTIBIOTIC
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- MEYERS E.
- Squibb Institute for Medical Research
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- SLUSARCHYK D. SMITH.
- Squibb Institute for Medical Research
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- PANSY F. E.
- Squibb Institute for Medical Research
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- BASCH H.I.
- Squibb Institute for Medical Research
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- TREJO W. H.
- Squibb Institute for Medical Research
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- DEBAECKE P. J.
- Squibb Institute for Medical Research
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説明
Diumycin, a phosphorus-containing glycolipid antibiotic, is produced by Streptomyces umbrinus ATCC 15972. It is active against gram-positive bacteria and, to a lesser degree, against gram-negative bacteria. Diumycin affects dividing but not resting cells of Staphylococcus aureus FDA 209 P. The antibiotic is strongly bound by serum. Although primarily bacteriostatic at levels approximating the minimum inhibitory concentration, it is bactericidal at higher levels. Diumycin is active upon subcutaneous administration to mice infected with Streptococcus pyogenes C 203 and Diplococcus pneumoniae and, like other members of the phosphorus-containing glycolipid antibiotic group, demonstrates a unique prophylactic activity against these infections. High and prolonged serum levels (lasting several weeks) were achieved in the plasma of dogs and monkeys after a single, parenteral dose of the antibiotic, and small to moderate amounts of bioactivity were recovered in the urine. Toxicity studies indicate that diumycin is well-tolerated in mice, but may cause a transient liver damage at dose levels near the LD50.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 25 (3), 163-170, 1972
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390282679130616960
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- NII論文ID
- 130003498512
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE38XksVeitb0%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 7673487
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- PubMed
- 5034812
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 使用不可