THE ANTIFUNGAL ACTIVITY OF DERMOSTATIN

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  • GORDEE R.S.
    The Lilly Research Laboratories, Eli Lilly and Company
  • BUTLER T.F.
    The Lilly Research Laboratories, Eli Lilly and Company
  • NARASIMHACHARI N.
    Antibiotics Research Centre Present address: Galesburg State Research Hospital

書誌事項

公開日
1971
資源種別
journal article
DOI
  • 10.7164/antibiotics.24.561
公開者
公益財団法人 日本感染症医薬品協会

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説明

Dermostatin is a polyene antibiotic which possesses a typical spectrum of antimicrobial activity. In vivo, by parenteral or oral administration, dermostatin was less effective than amphotericin B against Candida albicans. The in vivo activity of dermostatin was comparable to amphotericin B against Cryptococcus neoformans and Blastomyces dermatitidis ; amphotericin B was more effective than dermostatin against Histoplasma capsulatum. Further studies are needed to determine if dermostatin could be useful in the treatment of cryptococcosis or blastomycosis in man.

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