高感度甲状腺刺激ホルモンラジオイムノメトリックアッセイキットの基礎的検討

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  • Fundamental evaluation of highly sensitive thyroid stimulating hormone immunoradiometric assay kits.
  • コウ カンド コウジョウセン シゲキ ホルモン ラジオイムノメトリックアッセイ

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Usefulness of three kinds of TSH kits by immunoradiometric assay (IRMA) was evaluated. They were able to measure low levels (less than 0.1 μIU/ml) in serum thyroid stimulating hormone (TSH) with incubation of short time (4 hours) . In particular, RIABEAD II kit had a highly specific affinity for TSH and the normal range (±2 S.D.) using it showed from 0.20 to 3.50 μIU/ml in 150 normal subjects. In patients with hyperthyroidism and in patients with hypothyroidism, the values of TSH were lower and higher than those of normal subjects, respectively. Another kits showed similar results. These results indicate that these TSH-IRMA kits are useful to evaluate serum TSH levels exactly.

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