FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No.002: I.Taxonomy, Fermentation, Isolation and Physico-chemical Properties

KOBAYASHI MOTOO, KANASAKI RYUICHI, EZAKI MASAMI, SAKAMOTO KAZUTOSHI, TAKASE SHIGEHIRO, FUJIE AKIHIKO, HINO MOTOHIRO, HORI YASUHIRO

doi:10.7164/antibiotics.57.780

FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No.002: I.Taxonomy, Fermentation, Isolation and Physico-chemical Properties

DOI

KOBAYASHI MOTOO

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KANASAKI RYUICHI

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
EZAKI MASAMI

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SAKAMOTO KAZUTOSHI

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TAKASE SHIGEHIRO

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
FUJIE AKIHIKO

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HINO MOTOHIRO

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HORI YASUHIRO

Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd. PMD Research Center, Fujisawa Pharmaceutical Co., Ltd.

書誌事項

タイトル別名

I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties

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説明

A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210-211°C and possesses the molecular formula C₃₈H₅₈O₁₁.<br>FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1, 3-β-glucan synthase inhibitor.